產品屬性：
產品名稱 | Curzerene |
規格 | 1mg、5mg |
貨號 | EY-01Y16579 |
Cas No.: 17910-09-7
別名: N/A
化學名: N/A
分子式: C15H20O
分子量: 216.32
溶解度: DMSO: 250 mg/mL (1155.70 mM)
儲存條件: -20°C, protect from light, stored under nitrogen*Product is unstable in the solution state, it is recommended that you use it now and use it immediately
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis[1].GSTA1[1]Curzerene (0-100 μM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 μM, and 47.01 μM, respectively[1].Curzerene (0-100 μM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells[1].Curzerene(0-100 μM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose[1].Curzerene (6.25-100 μM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells[1].Curzerene (6.25-100 μM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells[1].Cell Viability Assay[1] Cell Line:SPC-A1 cells[1]. Wang Y, et al. Cytotoxic and Antitumor Effects of Curzerene from Curcuma longa. Planta Med. 2017 Jan;83(1-02):23-29.
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