產品屬性：
產品名稱 | Atorvastatin-d5 (calcium salt) |
規格 | 500 μg、1 mg |
貨號 | EY-01Y16751 |
Cas No.: 222412-82-0
別名: N/A
化學名: N/A
分子式: C29H30D5FN2O5.1/2Ca
分子量: 582.7
溶解度: DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: 0.50 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Atorvastatin-d5 is intended for use as an internal standard for the quantification of atorvastatin by GC- or LC-MS. Atorvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol synthesis, that has IC50 values of 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively.1 Formulations containing atorvastatin have been used in the treatment of hypercholesterolemia and certain dyslipidemias.1.Shaw, M.K., Newton, R.S., Sliskovic, D.R., et al.Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductaseBiochem. Biophys. Res. Commun.170(2)726-734(1990)
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