產品屬性：
產品名稱 | α,β-Methyleneadenosine 5'-triphosphate (sodium salt) |
規格 | 1mg、5mg、10mg |
貨號 | EY-01Y16889 |
Cas No.: 1343364-54-4
別名: αβ-methylene ATP
化學名: 5'-[hydrogen P-[[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate] adenosine, trisodium salt
分子式: C11H15N5O12P3?3Na
分子量: 571.2
溶解度: 10 mg/ml in PBS (pH 7.2)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
α,β-Methyleneadenosine 5’-triphosphate (αβ-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the α- and β-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X1 and P2X3 (EC50 = ~1 μM) and is ~1,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors. [1][2][3][4] Persistent activation of purinoceptors results in desensitization, resulting in an antagonist-like effect of αβ-methylene ATP. [5] αβ-methylene ATP is used as a stable analog of ATP to study the interaction of ATP with kinases and other proteins. [6][7] It weakly binds and inhibits adenylate cyclase in a calcium-dependent manner (Ki= ~0.5 mM). [8][9]
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