產品屬性：

Cas No.: 73607-83-7

別名: N/A

化學名: N/A

分子式: C4HD7O2

分子量: 95.1

溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Butyric acid-d7 is intended for use as an internal standard for the quantification of sodium butyrate by GC- or LC-MS. Butyric acid is a short-chain fatty acid.[1] It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.[1],[2] Butyric acid is an inhibitor of histone deacetylase (HDAC; IC50 = 90 μM in a cell-free assay).[3] It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM.[2],[5],[6] Butyric acid decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mM.[5] It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day.[4] Butyric acid also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis.[7]

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