產品屬性：
產品名稱 | CAY10575 |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y16996 |
Cas No.: 916985-21-2
別名: N/A
化學名: N/A
分子式: C22H21N3O6S2
分子量: 487.6
溶解度: DMF: 1mg/mL,DMSO: 10mg/mL,DMSO:PBS(7.2pH) 1:4: 0.2mg/mL
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKK-α and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells and is thought to play a role in the immune response. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 μM.
特別提醒公司產品僅供科研使用
