產品屬性：
產品名稱 | (S)-3'-amino Blebbistatin |
規格 | 500μg、1mg、5mg |
貨號 | EY-01Y17044 |
Cas No.: 2097141-18-7
別名: N/A
化學名: N/A
分子式: C18H17N3O2
分子量: 307.3
溶解度: DMF: 20 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 12.5 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
(S)-3'-amino Blebbistatin is a more stable and less phototoxic form of (-)-blebbistatin , which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases. (-)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM). Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a 3'-amino group decreases the inherent fluorescence while retaining the activity of (-)-blebbistatin. (S)-3'-amino Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.
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