產品屬性：

Cas No.: 63-25-2

別名: NAC

化學名: N/A

分子式: C12H11NO2

分子量: 201.2

溶解度: Chloroform: Slightly Soluble,Methanol: Slightly Soluble

儲存條件: Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Carbaryl is a carbamate insecticide that inhibits acetylcholinesterase (AChE; IC50 = 13.6 nM for A. gambiae AChE2 expressed in Sf9 cells; Ki = 5.7 μM for rat brain AChE).1,2 Carbaryl administered at a dose of 30 mg/kg for 28 days in rats decreases the weight of spleen and thymus, proliferation of lymphocytes, and serum levels of IL-2, IFN-γ, IL-1β, and TNF-α, and increases the serum levels of IL-4 and IL-10.3 It increases CaMKII, GAP-43, and tau protein levels in the hippocampus and tau levels in the cortex of mice 24 hours after administration of doses ranging from 0.5 to 20 mg/kg on postnatal day ten, whereas tau protein levels are decreased four months after administration with no change in CaMKII or GAP-43 compared with control mice. These effects occur at non-toxic doses where acetylcholinesterase is inhibited only during the first six hours following treatment. Formulations containing carbaryl have been used to control insects in agriculture.

1.Zhao, P., Wang, Y., and Jiang, H.Biochemical properties, expression profiles, and tissue localization of orthologous acetylcholinesterase-2 in the mosquito, Anopheles gambiaeInsect. Biochem. Mol. Biol.43(3)260-271(2013) 2.Hassan, A., Abdel-Hamid, F.M., and Bahig, M.R.E.Kinetics of inhibition of rat brain acetylcholinesterase by SevinZ. Naturforsch. B.22(5)505-507(1967) 3.Jorsaraei, S.G., Maliji, G., Azadmehr, A., et al.Immunotoxicity effects of carbaryl in vivo and in vitroEnviron. Toxicol. Pharmacol.38(3)838-844(2014)
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