產品屬性：
產品名稱 | BEC (hydrochloride) |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y17218 |
Cas No.: 222638-67-7
別名: N/A
化學名: N/A
分子式: C5H12BNO4S?HCl
分子量: 229.5
溶解度: PBS (pH 7.2): 10 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM (ph 7.5).target: Arginase II [1];In vitro: BEC hydrochloride causes significant enhancement of NO-dependent smooth muscle relaxation in this tissue. [2] BEC hydrochloride enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness. [3] In vivo: BEC hydrochloride increased contractility in isolated myocytes from WT and NOS3 but not NOS1 knockout mice. [4]
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