產品屬性：
產品名稱 | CPYPP |
規格 | 10 mg、50 mg |
貨號 | EY-01Y17436 |
Cas No.: 310460-39-0
別名: N/A
化學名: N/A
分子式: C18H13ClN2O2
分子量: 324.76
溶解度: DMSO: 50 mM
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.Nishikimi et al (2012) Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem.Biol. 19 488 PMID:22520755 |Laurin et al (2013) Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc.Natl.Acad.Sci.U.S.A. 110 7434 PMID:23592719
特別提醒公司產品僅供科研使用
