產品屬性：
產品名稱 | BGT226 |
規格 | 5mg、10mg、50mg |
貨號 | EY-01Y17650 |
Cas No.: 915020-55-2
別名: N/A
化學名: N/A
分子式: C28H25F3N6O2
分子量: 534.53
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells[1][2].
PI3Kα|4 nM (IC50)|PI3Kβ|63 nM (IC50)|PI3Kγ|38 nM (IC50)|mTOR Autophagy
BGT226 shows significant growth inhibition or signal blockage profiles compared with LY294002 and Rapamycin. BGT226 (10-10000 nM) inhibits FaDu and OECM1 cells growth with IC50s of 23.1±7.4 and 12.5±5.1 nM, respectively[2].The expression levels of p-mTOR Ser2481 are decreased in BGT226-treated cell lines (200 nM; 24 hours) and both p-AKT Ser473 and p-mTOR Ser2448 are also decreased in BGT226-treated cell lines[2].Cell Viability Assay[2]Cell Line:FaDu cells; OECM1 cellsBGT226 (2.5 and 5 mg/kg; oral administration for 21 days in male athymic mice) causes 34.7% and 76.1% reduction of the tumor growth on day 21 compared with control[2].
特別提醒公司產品僅供科研使用
