產品屬性：
產品名稱 | BMS 345541 (trifluoroacetate salt) |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y17820 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C14H17N5?2CF3COOH
分子量: 483.4
溶解度: PBS (pH 7.2): 10 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM). It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 μM. BMS 345541 inhibits signaling through nuclear factor-κB (NF-κB) both in cells and in vivo, showing excellent pharmacokinetics in mice. It blocks joint inflammation and damage in collagen-induced arthritis in mice and induces apoptosis in melanoma cells both in vitro and in vivo. BMS 345541 is used to explore novel roles for IKK phosphorylation and NF-κB signaling.
特別提醒公司產品僅供科研使用
