產品屬性：
產品名稱 | DAMGO (trifluoroacetate salt) |
規格 | 1 mg、5 mg、10 mg、25 mg |
貨號 | EY-01Y17916 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C26H35N5O6.XCF3COOH
分子量: 513.6
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 5 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
DAMGO is a selective peptide agonist of the μ-opioid receptor (Kis = 1.18, 1,430, and 213 nM for human μ-, δ-, and κ-opioid receptors, respectively).1,2 DAMGO displays higher efficacy than morphine for μ-opioid-induced nociception in rats.3,41.Hirning, L.D., Mosberg, H.I., Hurst, R., et al.Studies in vitro with ICI 174,864, [D-Pen2, D-Pen5]-enkephalin (DPDPE) and [D-Ala2, NMePhe4, Gly-ol]-enkephalin (DAGO)Neuropeptides5(4-6)383-386(1985)
2.Zhao, G.-M., Qian, X., Schiller, P.W., et al.Comparison of [Dmt1]DALDA and DAMGO in binding and G protein activation at μ, δ, and κ opioid receptorsJ. Pharmacol. Exp. Ther.307(3)947-954(2003)
3.Fang, F.G., Haws, C.M., Drasner, K., et al.Opioid peptides (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: Comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medullaBrain Res.501(1)116-128(1989)
4.Kelly, E.Efficacy and ligand bias at the μ-opioid receptorBr. J. Pharmacol.169(7)1430-1446(2013)
特別提醒公司產品僅供科研使用
