產品屬性：
產品名稱 | BPN14770 |
規格 | 10mM * 1 mL in DMSO、5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y17985 |
Cas No.: 1606974-33-7
別名: N/A
化學名: N/A
分子式: C21H15ClF3NO2
分子量: 405.8
溶解度: DMSO: 260 mg/mL (640.71 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively[1].
PDE4D3|7.4 nM (IC50)|PDE4D7|7.8 nM (IC50)
BPN14770 increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus[1].BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg[2].
特別提醒公司產品僅供科研使用
