產品屬性：
產品名稱 | MMG-0358 |
規格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y18159 |
Cas No.: 1378976-02-3
別名: N/A
化學名: N/A
分子式: C8H6ClN3O
分子量: 195.6
溶解度: DMF: 20mg/mL,DMF:PBS (pH 7.2) (1:4): 0.2mg/mL,DMSO: 15mg/mL,Ethanol: 15mg/mL
儲存條件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
MMG-0358 is an inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50s = 2 and 80 nM for the mouse and human enzyme, respectively).1,2 It is selective for IDO1 over tryptophan 2,3-dioxygenase (TDO; IC50s = >100 μM for mouse and human TDO).11.R?hrig, U.F., Majjigapu, S.R., Grosdidier, A., et al.Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibitionJ. Med. Chem.55(11)5270-5290(2012)
2.R?hrig, U.F., Reynaud, A., Majjigapu, S.R., et al.Inhibition mechanisms of indoleamine 2,3-dioxygenase 1 (IDO1)J. Med. Chem.62(19)8784-8795(2019)
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