產品屬性：
產品名稱 | Alyssin |
規格 | 1 mg、5 mg、10 mg、25 mg |
貨號 | EY-01Y21220 |
Cas No.: 646-23-1
別名: N/A
化學名: N/A
分子式: C7H13NOS2
分子量: 191.3
溶解度: Chloroform: soluble,DMSO: soluble,Ethanol: soluble
儲存條件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Alyssin is an isothiocyanate that has been found in W. japonica and has diverse biological activities, including antibacterial, fungicidal, CYP inhibitory, and antiproliferative properties.1,2,3 It is active against the bacteria B. subtilis, methicillin-sensitive S. aureus, methicillin-resistant S. aureus (MRSA), and E. coli, and the plant pathogenic fungus A. niger.1 Alyssin (0.5-2.5 μM) directly inhibits activity of the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2 induced by the polycyclic aromatic hydrocarbons (PAHs) anthracene and dibenzo[a,h]anthracene in MCF-7 breast cancer cells.2 It inhibits proliferation of HCT116 colon cancer cells (IC50 = <4 μM).3 Alyssin also inhibits platelet aggregation induced by ADP or arachidonic acid (IC50s = 168 and 20 μM, respectively).41.Masuda, H., Harada, Y., Kishimoto, N., et al.Antimicrobial Activities of IsothiocyanatesAroma Active Compounds in Foods229-250(2001)
2.Skupinska, K., Misiewicz-Krzeminska, I., Lubelska, K., et al.The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cellsToxicol. In Vitro23(5)763-771(2009)
3.Kim, M.J., Kim, S.H., and Lim, S.-J.Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cellsAnticancer Res.30(9)3611-3619(2010)
4.Morimitsu, Y., Hayashi, K., Nakagawa, Y., et al.Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, WasabiMech. Ageing Dev.116(2-3)125-134(2000)
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